A group of scientists in an underwater laboratory, the Aquatica, are experimenting with Mako sharks seeking to cure human brain ailments. The unintended result of the experimentation is a breed of Mako that is bigger, smarter, faster and meaner that any other – a perfect killing machine.

When the increasingly uneasy financial backers of the project show up and threaten to close-down the research on the eve of key tests, the entire group on the Aquatica are now stranded by a major tropical storm and predatory monster Mako sharks stalking them as the Aquatica sinks.