Abby Barnes (Janeane Garofalo) should have it all. She’s a veterinarian and successful host of her own radio talk show called “The Truth About Cats and Dogs,” where she entertainingly dispenses useful advice to befuddled pet owners (“It’s O.K. to love your pet, but you shouldn’t love your pet,” she tells a listener who’s let his cat lick his face for hours, not surprisingly inducing a rash ). Abby’s smart, funny, and plays a mean violin. But she’s not tall and blond–and routinely gets overlooked when it comes to romance.

Noelle Slusarsky (Uma Thurman), on the other hand, is tall and blonde. She’s also kind, generous, and a little lost. Her career as a model isn’t all that satisfying, and her relationships with men could provide fodder for a multi-part series on Oprah, Jenny and/or Ricki.

Enter Brian (Ben Chaplin), a photographer who finds himself on the wrong end of a roller skating Great Dane. He turns to radio host Abby for help, and he’s charmed when she solves his snarling problem with a dose of common sense combined with disarming humor and grace.

Intrigued by Abby’s beguiling charm, evident to him even over the radio airwaves, Brian invites her to meet him so he can thank her in person. Abby nearly agrees, that is until he utters those dreaded five words– “What do you look like?” Rather than suffer what she is sure will be another rejection, Abby describes herself as a tall blonde (who looks very much like her neighbor Noelle), and makes plans–with the intention of never keeping them–to meet Brian.

But the persistent and besmitten Brian seeks out Abby, finding her at work. A panicked Abby asks Noelle, who happens to be visiting Abby at the station, to assume Abby’s identity, setting in motion an escalating series of comic and romantic crises. Without knowing what’s hit him, Brian falls head-over-heels for someone who could very well be his perfect soul mate. But, in the process, he’s also going to discover the not-so-simple truth about the woman he loves..That she’s really not the woman he loves.