George Hanson (Paul Rudd) is at a dinner party when he learns from a total stranger (Jennifer Aniston) that he’s about to be dumped. Fortunately, Nina Borowski is sympathetic, even offering him the spare room in her Brooklyn apartment. So when his handsome boyfriend, a college professor named Dr. Joley (Tim Daly) hesitantly admits that their relationship is over, George accepts Nina’s generous invitation — and the most important relationship of their lives begins.

In the months that follow, Nina and George will become the best of friends -family — a fact which is mildly unsettling to her devoted boyfriend Vince (John Pankow). But what disturbs the hard-driving civil liberties lawyer even more is Nina’s announcement that she is pregnant, and she wants to raise the baby with her gay roommate instead of him.