Man with the Screaming Brain is a story of greed, betrayal and revenge in a small Bulgarian town. William Cole, wealthy industrialist, winds up with part of his brain replaced by that of a Russian cab driver Yegor. The two couldn’t be more different, but they share one thing – both were killed by the same woman. Brought back to life by a mad scientist, William and Yegor form an unlikely partnership to track down their common nemesis.