In the early 22st century, the crew of the medical rescue vessel Nightingale 229 has recently departed for a routine patrol of deep space. On this quiet, lonely ship, it’s business as usual for Captain A.J. Marley (Robert Forster), co-pilot Nick Vanzant (James Spader), chief medical officer Kaela Evers (Angela Bassett), computer engineer Benj Sotomejor (Wilson Cruz), medical tech Yerzy Penalosa (Lou Diamond Phillips) and paramedic Danika Lund (Robin Tunney).

The mission changes quickly, though, when they respond to a distress signal from a comet mining operation millions of light years away. Rescuing a mysterious young man, the crew is imperiled by the refugee and the alien artifact he’s smuggled on board. To make matters worse, they are caught in the powerful cosmic whirlpool of a blue giant star about to implode (go “supernova”).