This time around, Carmen (Alexa Vega) and Juni Cortez (Daryl Sabara) find themselves on a mysterious island, where they meet an eccentric scientist (Steve Buscemi) and his odd genetic creations, all the while battling a pair of rival spy siblings, Gary (Matt O’Leary) and Gerti (Emily Osment) Giggles. When the kids find themselves in trouble, mom and dad (Carla Gugino, Antonio Banderas) spring into action, and even their superspy grandparents (Ricardo Montalban, Holland Taylor) lend a hand.