Darryl Witherspoon (Marion Wayans) is an impoverished but brilliant economics student on a personal mission to pay his college tuition and earn enough money to keep his single mom and younger brothers and sisters afloat.

He enters an employment competition, where he stands to gain an ample salary and a world of opportunity. The odds are against Darryl, but he has drive and heart. While engaged in the competition, he also participates in a well-paying medical experiment for a little extra cash.

When the drug being tested heightens his every bodily sensation, things spin out of control and Darryl loses his senses — one at a time — rendering him utterly and hilariously Senseless.