When the virus (voiced by Laurence Fishburne) invades Frank’s body, renegade white blood cell Osmosis Jones (voiced by Chris Rock) springs into action to hunt down and destroy it. Unfortunately, he’s stuck with his partner Drix (the voice of David Hyde Pierce), a painkiller-packing 12-hour cold capsule who can be a bit of a pain himself. Together they race against the biological clock to save Frank from certain death, dodging mucus mud slides, toxic spills, hurricane-force sneezes and things you’ve got to see to believe.

It’s a dirty job but some antibody’s got to do it.