A brilliant geneticist, Dr. Moreau (Brando) and his assistant Montgomery (Kilmer) are on the brink of revolutionizing science when Edward Douglas (Thewlis) becomes stranded on their remote island. Deep in the jungle, beneath the seemingly idyllic tropical paradise, lies a terrifying secret. Moreau and Montgomery have been performing gene-splicing research on animals to create a superior breed of human being, and that experiment has gone terribly wrong.

Moreau’s beast-people are highly intelligent with murderous instincts. Their thirst for blood is pacified through a combination of sedatives and shock discipline. But events triggered by Douglas’ unexpected arrival are about to break Moreau’s God-like dominion over these resentful creatures. Douglas must escape Moreau’s clutches before he becomes a part of a final horrifying experiment.