Anton (Devon Sawa) wakes up Halloween morning to discover-after doing a little channel surfing and perusing the contents of the fridge, oblivious to the pool of blood on the floor – that his lovable Dad (Fred Willard) and Mom (Connie Ray) have been turned into a couple of headless Halloween decorations. A prime candidate for America’s Most Wasted, Anton steals some pocket money and heads over to visit his equally irresponsible friends, Mick (Seth Green) and Pnub (Elden Henson). On the way, he catches a tasty glimpse of Molly (Jessica Alba), the girl next door who has been the love of his life.

Hanging out with Mick and Pnub, Anton – who generally opts for MTV over the evening news-learns of several recent murders that have their hometown of Bolan scratching its head and shaking in its boots. As they piece together clues, Anton discovers that he may be responsible – apparently his right hand has a very bloodthirsty mind of its own, and it’s hell-bent on wreaking deadly havoc with or without him. Meanwhile, while Anton has been arm wrestling with his possessed limb, Debi (Vivica A. Fox) has been racing across the country following a trail of suspicious events – leading right to Northern California and Anton’s home town!