Here's some news you'll have to take with a grain of salt. The James Cameron remake of FANTASTIC VOYAGE has been roasting on a spit in Production Hell since the late 2000's. But currently Cameron's company Lightstorm Entertainment is in talks with genre maven Guillermo del Toro to helm that very film.
Seeing that del Toro is notorious for having great sounding projects slip through his fingers (including the shelved PACIFIC RIM 2), it's hard to hold out hope that this will happen. If it does, though, wouldn't that be incredible? The property has been imitated dozens of times throughout the years, but del Toro could put a truly unique spin on the film that nobody else in the world could duplicate.
In the original 1966 FANTASTIC VOYAGE:
The brilliant scientist Jan Benes develops a way to shrink humans, and other objects, for brief periods of time. Benes, who is working in communist Russia, is transported by the CIA to America, but is attacked en route. In order to save the scientist, who has developed a blood clot in his brain, a team of Americans in a nuclear submarine is shrunk and injected into Benes' body. They have a finite period of time to fix the clot and get out before the miniaturization wears off.
The story treatment was penned by David Goyer with a script by Justin Rhodes. Something tells me that there might be fewer commies in their draft. More on this story if it breaks!